Picking up a Blood Stone and using it from the inventory will have the same effect. The disease can only be cured by coming into contact with a Blood Stone, which will also heal all the player characters of all ailments and restore their hitpoints. While Rot causes the character to take 1 damage per second and cannot be healed by conventional means, the disease won't actually kill player characters, instead bringing them down to just one hitpoint. Mechanically, having a player character pick up any Tenebrium item (such as Tenebrium ore or a Tenebrium weapon) will cause the character to contract Rot 1 non-leathal Void Damage per Turn, the worst disease in the game. The mineral plays an important part in multiple quests, including The Naked Truth, The Troll's Bounty, and the main storyline quest A Source Hunter's Journey. The player first hears about Tenebrium in the mining town of Silverglen, where people have died of a disease called Rot after working in a nearby mine to extract Tenebrium. It is also the material used to build the Tomb of Lucian in Arx.
It also makes a minor appearance in Divinity: Original Sin 2 in the form of a Tenebrium chest during the quest The Secrets of Bloodmoon Island.
Tenebrium is black mineral that appears and plays a major part in Divinity: Original Sin.